For a class of uncertain networked control system(NCS) with time-varying delay and data packet dropout, the problem of multi-constraints robust fault-tolerant control for NCS with actuator structural failures is discussed by using state feedback control strategy. The effect of actuator saturation, nonlinear perturbation and controller parameter perturbation are considered simultaneously. Based on a class of delay-dependent Lyapunov method and a definition of the domain of fault-tolerant attraction, the set of invariance conditions of the closed-loop uncertain NCS against actuator structural failures isderived, and the design method of non fragile robust fault-tolerant controller is given. The domain of fault-tolerant attraction of the closed-loop system is estimated. A simulation example shows the effectiveness and the feasibility of the proposed approach.