Safe decision and control is one of the most significant technologies that ensure stable and safe operations of control systems. Three different types of abnormal behaviors, namely physical faults, cyber attacks and malicious decision may take place respectively on the physical, cyber, individual decision and supervisory layers of the modern network systems. Firstly, this paper summaries the characteristic of each abnormal behavior, and points out the goals and difficulties in the safe decision and control of network systems. The features and merits of the fault-tolerant game control is emphasized by comparing to the other fault-tolerant control methods and game methods. Secondly, this paper focuses on characteristics of these abnormal behaviors and introduces the basic problems and main ideas of fault-tolerant game design based on the cross-layer adjustment. The latest works on fault-tolerant game methods are summarized with respect to their features. An example of the swarm control systems is taken to illustrate the application prospects of fault-tolerant game control. Finally, some prospectives are also provided.