For T/R(transmit/receive) module, the core component of active phased array radar, the concept of comprehensive vulnerability assessment and its mathematical model expression are proposed, and a quantitative evaluation method of game combination weighting-good and bad distance solution is presented. Firstly, the vulnerability assessment criteria are constructed respectively from two levels of components and systems. The fault tree is established by using the physical characteristics of components, and the physical vulnerability index(i.e., reliability index) of operating state is obtained based on Monte Carlo simulation calculation. According to the circuit structure of the system, the topological network is established and the structural vulnerability index is calculated. Then, a mathematical model of comprehensive vulnerability assessment integrating physics and structure is proposed, and the game combination weighting problem is established to optimize the combination weight. The quantitative assessment of comprehensive vulnerability of T/R components is realized by combining the superior and inferior solution distance method. The experimental results show that the comprehensive vulnerability of T/R components is not only related to the inherent reliability level of each component, but also closely related to the circuit network topology of the system. The established comprehensive vulnerability assessment model can identify the weak links effectively and reasonably.