Through analyzing and studying the characteristics of the biological immune system (BIS) and the intelligence
recognition technology of SoftMan, a concept of immune-SoftMan(ISM) is proposed. The basic attribute of ISM is presented, and a formalized negotiation control model based on multi-ISM alliance is designed. This model can monitor the distributed dynamic network environment in real time, and alarm and diagnose faults in advance, based on which, a novel negotiation control algorithm based on multi-ISM is also constructed. The presented model and algorithm can achieve a self-organizing system that is more robust and flexible in dynamic network environment and can be self-updated locally.