A switching control system of boiler’s superheated steam temperature based on single-neuron self-adaptive proportional sum differential(PSD) predictive controller is proposed in this paper, in which a compound controller to improve the control characteristics of large-lag and multi-interferer systems is combined with single-neuron self-adaptive PSD controller and Levinson predictive controller. Configuration design including undisturbed switching, feed-forward compensation and anti-saturation of integrator is made with DCS control platform of Foxboro I/A series to realize manual/auto switch and switching between controllers. A large number of simulations in the lab and practical results in the power plant show the satisfactory control quality.