The reliability computing formula of supply chain is achieved based on the analysis and judgment of supply chain reliability within the strategy synergetic networks. Accounting to the statistical characteristic of supply chain reliability of the strategy synergetic networks, there are three estimation methods, two Bayesian estimation methods and one hierarchical Bayesian estimation method, used for the evaluation of supply chain specimen's reliability. The test of the estimation of supply chain reliability shows that the hierarchical Bayesian estimation method is more effective than others.