Asymmetric LSB hiding algorithm of resisting SPA(ALRS) is a least significant bit(LSB) information hiding algorithm of resisting sample pair analysis(SPA), which is able to analyze some properties of the image fixel pairs. Based on the properties, a monotonous sequence of restoration is found by using ALRS. The sequence can amend the statistic properties of the pair. The experiment results show that the method can resiste the attack of SPA and its performance is better than others in the efficiency and security of information hiding.