This paper researches the problem of optimal response to disruptions under revenue-sharing contract when both demand and price are response time sensitive. Firstly, the coordination model under normal conditions are given. Then, the influence of disruptions to the supply chain is discussed when demand perturbation factor distribution is fluctuated by disruptions, and the optimal react strategy is given. Finally, an adjusted revenue-sharing contract is proposed, and it is proved that the new contract can coordinate the supply chain and achieve optimal reaction.