Based on the background of gas-steam combined cycle power plant gas system of a steelworks, a mechanism model suitable for the anti-surge control design of compression system is established based on the loss mechanism of compressor. The improved adaptive genetic algorithm is applied to determine the important parameters of the model. Based on the developed model, the corresponding anti-surge control strategy is proposed. Applying the mechanism model and antisurge control strategy to the practical gas system, the results show that the model has satisfactory prediction performance and the control strategy proposed can provide effective control in inhibiting the occurrence of compressor surge, and achieve good control effect.