The full matrix controller design problems are investigated for high dimensional multivariable processes based on the equivalent transfer function(ETF). By employing the steady gain and response time, a new parameterization method of ETF is proposed. By exploiting the relationship between the ETF and the inverse of open-loop transfer function, an analytical expression of ETF is derived. Based on the obtained ETF, the centralized controller is designed by utilizing the existing PID tuning rules. Several typical industrial process examples are employed to demonstrate the effectiveness and simplicity of the design method.