In order to improve the hit rate, flexibility and fuel efficiency of intercepting large maneuvering target, a fuzzy sliding mode method for integrated guidance and control system is designed. Then integrative model of missile interceptors is built, ZEM(zero effort miss) is chosen as sliding mode surface, and the controller is integrated with the guidance law, merging kinematics and dynamics. For avoiding the chattering problem, fuzzy link is added in the sliding mode. Finally, trajectory simulation are carried out when the target has snake maneuver, and simulation results show the method can improve several system performances.