Aiming at the problem of rescheduling triggering mechanism in manufacturing shops, the rescheduling gain and loss functions are established to reveal the law of tradeoff between profit and cost during the rescheduling process. The cloud theory is applied to measure the uncertainty of rescheduling tradeoff. Then the reverse cloud algorithm is used to calculate the numerical characteristics of gain and loss cloud. Furthermore, the cloud shape is used to predict the tendency of rescheduling tradeoff. A decision method based on the gain-loss cloud model is proposed to determine whether or not reschedule, and the pre-schedule that ensures the stability and efficiency of production system can be selected by using the optimal gain-loss ratio. Finally, an example is given to demonstrate the rationality and feasibility of the method.