The robust operation problem of an uncertain dynamic supply chain network based on switched inventory is studied. Firstly, a discrete T-S fuzzy model of the dynamic supply chain network with uncertainties of the system parameters and the customers’ demands is established. Then, a new fuzzy robust control strategy is proposed, and this control strategy can not only effective reduce the large fluctuation among subsystems in the switching processes, but also suppress the effect on the supply chain network caused by uncertainties. Therefore, under this control strategy, the supply chain network can operate robustly stable in the uncertain environment. Finally, a simulation example is given to show the effectiveness of the proposed fuzzy robust control strategy.