The problem of unitized three-stage operational chain for material handling operations with key resource priority conditions is studied, including three sub-processes: loading, unloading and transport. Based on the known scheduling scheme of the key resource, the two non-critical stage scheduling problems are converted into the minimum unit flow problem respectively, and the corresponding 0/1 integer programming models are established. In order to solve the largescale problem, time-dependent clustering and coordination strategies are developed. In the background of real Ningbo port terminal, the numeric study is conducted to verify the effectiveness of the model and strategy.