The dual-channel supply chain under O2O mode completely changes price competition in the traditional channels. Price mechanism and service level have become two key factors in the operation of O2O supply chains. When the disruptions of the market demand and the service substitution coefficient in the supply chain take place, the decision value under different scenarios in the vertical manufacturer’s O2O supply chain and the horizontal retailer’s O2O supply chain can be obtained by using KKT conditions. The two-part-tariff contract is used to coordinate the O2O supply chain when the disruptions of the market demand and the service substitution coefficient occur simultaneously. The result shows that the two-part-tariff contract can coordinate the retailer’s O2O supply chain with disruptions. When the disruptions are large, as the leader of the Stackelberg game, the retailer gives up increasing retail price and turns to charge fixed transfer payment.