For the drawbacks that research on production, transportation and pricing decision problems has typically focused on considering individual production/pricing problems, or on considering individual transportation problems, the integrated decision-making model is proposed. The production decisions, transportation decisions and pricing decision are considered as a system, and an integrated decision-making model considering simultaneously production cost, transportation cost and the market demand is proposed by using the profit network graph. The solution and its theoretical basis are discussed. An application example is given to illustrate that, by using the mode, the increase in total operating profit from tradition model is up to 15.50%.