Considering the differential pricing problem of the closed-loop supply chain, the manufacturer collects used products and produces new products and remanufacturing products, and the remanufacturing rate is random. The Stackelbery game of the manufacturer leader is adopted to research the product differential pricing strategy under centralized decision- making and decentralized decision-making, and gives the profit of each member in the supply chain under two decision making. The research shows that when manufacturers have the opportunity to delay on product pricing, the centralized decision making recovery price of used products is higher than the decentralized decision making, and product prices are less than the decentralized decision making. When the retailer’s fundamental profit can achieve a certain value, the total profit under centralized decision making is not less than under decentralized decision making, thus the manufacturer can improve the two-tariff pricing contract to coordinate the supply chain.