The scientific dispatching of empty pallets based on the pallet pool can improve the utilization rate of pallets, improve transport efficiency, reduce resource consumption and save transport costs. Based on the pallet pool mode, this paper studies the scheme of empty pallet dispatching in the transport of highway and railway. To refine operation mode of node, it’s necessary to split the nodes of empty pallet dispatching network. The paper considers various factors of influencing the empty pallet transportation, according to the actual transport characteristics, takes the minimum total dispatching cost which includes shipping cost, inventory cost and rental cost as objective to construct optimization model, and constructs transit time optimization model of path based on the time constraint of customers for empty pallets dispatching. Using the ILOG Cplex mathematical software to solve the model. Finally, the feasibility and superiority of this model is confirmed by a case.