A multi-objective joint optimization problem combining the three-dimensional loading problem with the capacitated vehicle routing problem(3LCVRPMO) is proposed. In 3LCVRPMO, two targets including the minimum number of vehicles and the shortest distance of path are considered. An architecture of multi-stage or two layers hybrid algorithm(MSOTLH) is established to deal with path optimization preference of 3LCVRPMO based on trading off packing and path optimization. In numerical experiments, the relevant instances of the 3LCVRP are referenced, and the results show the effectiveness of the proposed 3LCVRPMO model and MSOTLH algorithm.