In view of the phenomenon that the signal transmission state of wireless sensor node is switched in the indoor complex environment, the non-line of sight location based on TODA and RSS for the feasible region particle filter is proposed. Firstly, the hypothesis testing method based on the two ranging models of the TDOA and RSS is used to identify whether there is non-line of sight(NLOS) in signals. Then, the position of unknown moving target node is located by using the method of feasible region particle filter based on the NLOS measurement information. Simulation results show that, the proposed method is better than the least square method, the ordinary particle filter algorithm and the particle filter algorithm with RSS ranging model, which has high positioning accuracy.