Aiming at the problem of selecting project risk response strategies considering risk interdependence, an optimization method is proposed. Firstly, the definition of risk interdependence is given and the method for measuring the degree of risk interdependence is proposed. Then, based on the analysis of risk interdependence, an optimization model with the consideration of project schedule, project quality and the implementation cost of risk response strategies is constructed. By solving this model, the desirable risk response strategies are obtained. Finally, a case study is given to illustrate the feasibility and effectiveness of the proposed method. The results show that the risk interdependence can impact the project risk response decisions and it is essential to consider the risk interdependence in the process of project risk management.