An integrated guidance and control(IGC) algorithm is proposed based on active disturbance compensation and dynamic surface control for the near space interceptor with aerodynamic force and reaction jets. A time-varying gain extended state obsever(TVGESO) is firstly constructed to estimate the unknown system disturbance, which can preserve the estimation accuracy as well as weakening the peaking phenomenon. Then, the model uncertainty caused by the target maneuvers and jet interaction is restrained with online estimation and compensation of the TVGESO, and the IGC algorithm is designed based on the integral sliding mode dynamic surface control. Finally, the closed loop system stability is proved by using the Lyapunov theory. Simulation results show the effectiveness of the proposed method.