Multiple time delays are not considered in exiting power and rate control methods for wireless communication networks. In order to deal with the multiple time delays, a robust power and rate control algorithm is presented. Firstly, based on the modelling and dynamics analysis of the power and rate control system, a new mathematical model is established for the power and rate control system with multiple time delays. The model contains time delays which are not only in rate control but also in power control and not only in system state but also in control input. Based on this model, a robust power and rate controller is designed by using predictive control approach and linear matrix inequality. Simulation results verify the effectiveness of the proposed controller.