Traffic control of urban road networks has a direct impact on the efficiency of traffic operation, and its optimization research has become one of the hotspots to solve the problem of urban traffic jam. In this paper, the peak traffic network is divided into oversaturated region and its associated areas, and the grey relational analysis and spectral clustering method are used to divide the associated areas. Then, a distributed traffic cooperative control model is proposed. Furthermore, a cooperative optimization solution of over-saturated region and its associated areas based on multidisciplinary design optimization is proposed. The optimization results of the algorithm are analyzed by setting up an example network model. The results show that the proposed method can significantly improve the traffic efficiency of the road network, and help to alleviate the traffic congestion and proliferation during rush hour.