For the T-S fuzzy system with unknown premise variables, a new observer-controller design method is proposed. While the premise variables are all unknown, the terms caused by the unknown premise variables in observer error equations are restricted by the Lipschitz conditions. Then, the system stability conditions are obtained based on the Lyapunov function method, and an eigenvalue matrix scaling method and a fuzzy Lyapunov function high gain observer method are proposed to calculate the observer-controller gains. Finally, based on the above two approaches, ship dynamic positioning simulation results are compared and analyzed, which show the effectiveness of the proposed methods.