In this paper, saturated incidence rate is considered to establish a SIRS (Susceptible-Infected-Recovered-Susceptible) model characterizing the spread of malicious virus in cyber-physical systems. To avoid the spread of malicious virus due to the occurrence of Hopf bifurcation, a hybrid bifurcation controller combining the parameter adjustment method and state feedback method is designed to research the Hopf bifurcation control of the cyber-physical systems, and establish the stability conditions and bifurcation criteria of the controlled system. The influence of the control gain parameter on the Hopf bifurcation point and the amplitude of bifurcation limit cycle is explored, and the relationship between the bifurcation threshold and the gain parameter is given.The numerical simulation results show that the hybrid bifurcation control strategy proposed in this paper can not only chance the position of Hopf bifurcation point, but also greatly adjust the amplitude of the limit cycle. It makes CPS generate the the expected dynamic behaviors to effectively reduce the impact of the malicious virus spreading.