This paper proposes a novel sliding mode control method for a class of uncertain systems with time-varying state delay and neutral delay. First of all, based on the global sliding mode control, a type of integral sliding surface with neutral time-delay is introduced to exhibits global robustness during the entire response. Then the Lyapunov function makes full use of the low bounds of time delay so that the conservative is lowered. In terms of the LMI, robust stable conclusions of sliding mode is proved. Fathemnore, an adaptive sliding mode controller is investigated and the system chattering is weaken by using the saturation function to replace the symbolic function. Finally, a numerical example is given to illustrate the applicability of the proposed method.