To address the issue of uncertain strict-feedback systems with full state asymmetric and time-varying constraints, a low-complexity pre-set time tracking scheme based on a dual-layer constraint structure is first presented in this article. Firstly, the constraint transformation function is constructed to implement constraints on states of the system directly, which transforms state constraints problem into the new states bounded problem, removing the feasibility conditions. Secondly, combining with a pre-set time function, a new coordinate transformation is introduced to construct the states and tracking errors, thereby, the dual-layer constrain structure is completed, in which the inner boundaries are used to deal with the constrained states and the virtual control and actual control signals are designed through the outer boundaries. Therefore, the potential singularity problem caused by the states approaching constraint boundaries is solved. Finally, the simulation results are presented to verify the effectiveness of the proposed scheme.