The development of industrial Internet has realized the “reduced manpower” and “unmanned” industrial production. At the same time, industrial control systems are also facing more information security threats. Aiming at the conflict between information security strategies and functional safety strategies and the conflict between the security and safety strategies decision objectives of the field end and the monitoring end of the unattended industrial control system in the implementation process of information security protection requirements, this paper proposes a multiple-objective collaborative decision method of security and safety strategies. The collaboration of information security strategies and functional safety strategies is realized by setting security and safety strategies collaboration rules. A risk return quantification model is constructed to quantify the risk return attributes of security and safety strategies and a conflict risk quantification model is constructed to quantify the increased conflict risk associated with implementing security and safety strategies. Combining the acceptable risk thresholds of each field end, a multi-objective optimization algorithm is used to achieve collaborative decision-making between the field end and the monitoring end of the unattended industrial control system. Finally, the effectiveness of the proposed method is verified through simulation using the unattended pressure fan control system in the coal mining industry.